Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell

Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum biological activities, particularly anticancer activity. This research reported the isolation elucidation structure sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well their cytotoxic Four compounds, namely eudesm-4(15)-ene-1?,6?-diol (1), allo-aromadendrane-10?,14-diol (2), allo-aromadendrane-10?,14-diol (3) guaianediol (4), were isolated for first time bark. The chemical all compounds was identified by spectroscopic analysis, including IR, MS, 1H-NMR, 13C-NMR DEPT, compared with previous spectral data. activity against MCF-7 breast cancer line examined using resazurin method. results showed 1 shown highest IC50 108.08 ± 0.58 µM.